ACTorNOT
Optimal treatment for women with a Persisting Pregnancy of Unknown Location—a Randomization Clinical Trial of women at risk for an ectopic pregnancy: Active Treatment versus Expectant Management (No Treatment) The "ACTorNOT TRIAL"
This is a randomized controlled trial to compare three currently available management strategies for women with a persisting pregnancy of unknown location (PPUL), which makes them at-risk for ectopic pregnancy. This is for stable women with a confirmed PPUL to be randomized to one of three strategies:
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Uterine evacuation followed by methotrexate (MTX) for some (those that have evidence of a non-visualized ectopic pregnancy)
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Empiric treatment with MTX for all
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Expectant management
Recruiting from clinical population only
Principal Investigator:
Dr. Kurt Barnhart, MD, MSCE
Sponsor:
UPenn
Study Coordinator:
Ashley Singer
215-615-4201
ashley.singer@uphs.upenn.edu